PKR-eIF2α Signaling Mediated Spatial Memory Impairment

PKR-eIF2ÃŽ ± Signaling Mediated Spatial Memory Impairment Strengthening MATERIAL Enacted PKR-eIF2ÃŽ ± flagging intervened spatial memory weakness, tau phosphorylation, Aî ² pathology, oxidative pressure, specifically synaptic protein misfortune in mice brought about by low degrees of Cu Mouse conduct examination. Morris water labyrinth test: MWM was proceeded as recently depicted (PMID:23402899) with minor alterations and the test was performed twofold blinded by the standard activity convention. The MWM comprised of a round pool (120 cm breadth, divider profundity 40 cm) in which all the mice were prepared to escape from water by swimming to a concealed stage (2 cm underneath water surface) whose area just be recognized by utilizing the visual fixes on the internal mass of the pool (Supplementary Fig. 3A). The water and the room temperature were kept at 23â ±1 à ¢Ã¢â‚¬Å¾Ã¦'. The pool was separated into four quadrants by an automated following programming (Huaibei Zhenghua Biologic Apparatus Facilities Limited Company, Huaibei, Anhui, China). The stage was found somewhere between the inside and the divider in one quadrant and kept up at a similar situation during all the investigation. The route test comprised of 4 preparing preliminaries for every day and 5 sequential preparing days. As can be found in Table 1, mice were discharged with their heads confronting the internal mass of the pool from the four quadrantal areas (N, E, SE, and NW) agreeing the succession as past report (Supplementary Fig. 3B) (PMID:17406317), and not permitted to swim and quest for the stage in excess of 60 s, after which they were guided to the stage and permitted to stay on it for 15 s. Each mouse was then come back to its confine for 30 min before its next preliminary. The inactivity to arrive at the concealed stage was recorded. At some point or six days after the finish of route test, mice got a test, in which the stage was expelled. Mice were discharged from the NE area and permitted to a 120 s swim to locate the past area of the stage. The swimming way, the time spent in every quadrant, the separation voyaged every quadrant, the test time, the stage crossing number, the all out separation voyaged, and the normal swimming pace was recorded by the modernized following programming. Y-labyrinth: In request to contemplate the PKR job in exploratory conduct and spatial memory, we played out the Y-labyrinth in the PKR+/+Tg+/ - and PKR+/ - Tg+/ - mice as portrayed already (PMID: 8986335, 1393562). Reaction to oddity was tried in a Y-labyrinth, receiving a two-preliminary methodology in this test. The contraption was furnished with dark materials with three indistinguishable arms every 50 cm long, 16 cm wide, and 32 cm high. Viewable signals produced using shaded paper with various images and the floor of the labyrinth was secured with ruined creature bedding (Beta wood chips). All the mice was performed with starvation treatment for 24h before Y-labyrinth. In preliminary 1, one arm was hindered with dark Plexiglas and alluded to as the â€Å"novel† arm in Trial 2. The staying two arms were assigned as the ‘start’ arm and â€Å"other† arm separately. Three arms were randomized between mice (however not for a similar mouse) to decrease arm predisposition impacts. Toward the beginning of testing, a mouse was set in the beginning arm and was permitted to investigate the beginning and different arms for 10 min (procurement preliminary). Toward the finish of Trial 1, the mouse was come back to its home pen and the bedding inside the labyrinth was blended to diminish the chance of utilizing smells as a prompt. After an intertrial stretch (ITI) of 1 h, the mouse was put in a similar beginning arm as in Trial 1. The recently blocked arm was opened in Trial 2 and the mouse was permitted to examine each of the three arms for 5 min (review p reliminary). The reliant factors estimated in Trial 2 were: (1) the measure of time spent in each arm for every moment; (2) the quantity of passages made into each arm for every moment (Entry). Those indexs reflect curious conduct (for example reaction to curiosity) and spatial acknowledgment memory of the beforehand unvisited arm. Venture down test: This test was utilized to gauge inhibitory evasion and transient memory, as per the recently depicted strategy (PMID: 24678498). The contraption included a plastic chamber (12x12x18cm) with a raised elastic stage (4.84.84.5cm) set on the left side divider. The floor was made of bore tempered steel bars (0.1cm long) set in equal, 0.5cm separated. On the principal preparing day, mice were presented to a 5-min adapting course, if the creatures ventured down from the stage, they were presented to an electric foot stun (36V, AC). After 24h, inactivity was rethought and recorded as the learning grade (inertness), which was taken as a proportion of memory maintenance. Every obtaining preliminary was performed 5min in the PKR+/+Tg+/ - and PKR+/ - Tg+/ - mice. Advantageous Table 1. Essential antibodies utilized for protein immunodetection in western blotch examination (WB), immunohistochemistry (IHC) and immunofluorescence (IF). Antigen Provider Application PAGE (%) Species source Brooding conditions Abdominal muscle weakening 8-OhdG US Biological, H9076-02 On the off chance that N/A Goat 10% NGS, 12h, 4㠢„æ' 1:200 acetylated-ÃŽ ±-Tubulin Santa Clause Cruz, sc-23950 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:5000 Application Cell flagging, #2452 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 AT8 Thermo, MN1020B WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 ATF-4 Abcam, ab50546 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 ATF-4 Abcam, ab50546 On the off chance that N/A Mouse 10% NGS, 12h, 4㠢„æ' 1:100 Aî ²42 Abcam, ab10148 IHC N/A Hare 10% NGS, 12h, 4㠢„æ' 1:100 BACE-1 Abcam, ab2077 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 CCS Abcam, ab16962 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:100 Cleave Cell flagging, #2895 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 CREB Cell flagging, #9197 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 complexin-1/2 Santa Clause Cruz, sc-33603 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 Cp Abcam, ab48614 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 Drebrin Cell flagging, #12243 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 eIF2ÃŽ ± Cell flagging, #5324 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 GSK-3î ² Cell flagging, #9315 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 JNK Cell flagging, ##9252 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 Nitro-Tyrosine Cell flagging, #9691 WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 NR2A Sub-atomic Probes, A-6473 WB 8 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:500 NR2B Sub-atomic Probes, A-6474 WB 8 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:500 PKR (N-Term) GenWay Biotech, GWB-A4757E WB 10 Hare 5% skim milk, 2h, O/N, 4㠢„æ' 1:500 p-PKR (Thr 451) Invitrogen, 44668G WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:500 p-eIF2ÃŽ ± (Ser51) Cell flagging, #3398 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 p-GSK-3î ² (Ser9) Cell flagging, #9336 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 p-CREB (Ser133) Cell flagging, #9198 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 p-JNK Cell flagging, #4671 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 p-PP2A Epitomics, 1155-1 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PP2A C subunit Epitomics, 1512-1 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PS396 Invitrogen, 44752G WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PS404 Invitrogen, 44-758G WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PSD-93 Cell flagging, #9445 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PSD-95 Cell flagging, #2507 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 PSD-95 Cell flagging, #2507 In the event that N/A Bunny 10% NGS, 12h, 4㠢„æ' 1:100 synapsin 1 Invitrogen, 51-5200 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 sAPPÃŽ ± Covance, SIG-39139 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 sAPPÃŽ ² Covance, SIG-39138 WB 10 Bunny 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 Tau-1 Chemicon, MAB3420 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:1000 Tau-5 Abcam, ab80579 WB 10 Mouse 5% skim milk, 2h, O/N, 4㠢„æ' 1:500 ÃŽ ±-tubulin Santa Clause Cruz, sc-58667 WB 8-10 Mouse 5% skim milk, 2h, O/N, RT 1:1000 ÃŽ ²-actin Santa Clause Cruz, sc-47778 WB 10 Mouse 5% skim milk, 2h, O/N, RT 1:1000 N/A, not appropriate; NGS, typical goat serum; O/N, over-night; RT, room temperature. Valuable FIGURES Valuable Figure 1. Substance of Cu in Serum and mind. (A-D) Total iron, zinc, calcium, magnesium content in the serum separately; (E-H) Total iron, zinc, calcium, magnesium content in the hippocampus individually; (I-L) Total iron, zinc, calcium, magnesium content in the cortex individually; *P<0.05, **P<0.001, ***P<0.01 versus the control (n=5 for each gathering). Beneficial Figure 2. The l

Project Manager Letter Essay

(your organization) will hold a two-day training camp in San Diego, California and Orlando, Florida on August 24 and 25, 2012. Both training camps happen in the inns we will remain at to make things simpler. Two groups of undertaking designers from (your organization) will head up this year’s profoundly instructive instructional occasions. Every day will comprise of around 5 hours of preparing and an inquiry and answer period. Breakfast, lunch and supper will be provided food so we can focus on preparing and permit everybody some an opportunity to chat with our advancement groups. The main preparing day of training camp will concentrate on the new consistence strategies being presented and address the new framework stage and UI. The subsequent day will focus on Structured Query Language (SQL) which will be utilized to keep up and recover data from the database. Online instructional online courses will likewise be accessible from our group during the seven day stretch of August 20-24, 2012 out of two hour fragments for five days that week. There will be schoolwork alloted in these courses which you will be required to finish so as to fabricate a base of comprehension. We like to prepare face to face however understand that our arrangements won't suit everybody. That is the reason we offer the online partner. For those going to face to face †there is the open door for every representative to acquire their organization one free hour of help for each fruitful finishing of the course. Toward the finish of the training camp meetings and weeklong web based preparing every member will comprehend the nuts and bolts of how their framework is sorted out, decides and guidelines that they should stay conscious of and where to go for assets. What's more, our SQL groundwork will give you the fundamentals for developing reports for your organization. Every member will likewise get the most recent variant of Microsoft SQL Server 2008 R2 programming just as Report Builder 3.0 for developing reports. What we will cover- In light of our company’s usage plan it is fundamental to incorporate our business data frameworks into a solitary innovation stage utilizing a typical database improvement condition. We initially should specific spotlight on actualizing a corporate-wide Enterprise Resource Planning (ERP) programming framework. The ERP framework will turn into the center innovation, database, and advancement condition utilized by our organization. The new consistence framework will refresh every pertinent law and guidelines of the company’s inner standards and guidelines. The new consistence framework will turn into the center component of our comprehension of uprightness. Who is included The partners of this undertaking are on the whole representatives companywide. They will be acquainted with the new consistence framework. Prerequisite for chiefs are to prepare at least 10 hours on the new stage just as other new consistence arrangements. The new stage will incorporate the company’s everyday activities into a typical database. That database will be utilized to get to the data contained in various tables that the organization and advancement groups will make. Task Objectives This task will actualize another ERP programming framework stage that will incorporate our association companywide frameworks. ERP will consolidate, sort out, and keep up the information fundamental for activities. We will have the option to consolidate each of the company’s key activities, including the assembling, conveyance, monetary, HR, and client relations offices, into one programming framework and database framework. The new consistence framework is to guarantee we are inside guidelines and laws that direct the treatment of electronic data and individual information. All participants will round out an endless supply of the course. These will be utilized to assess our team’s capacity to impart the fundamental data. These will be accessible in online variants for our customers who can't go to the training camp meetings and take an interest in the online courses. Each participant’s organization area will get one hour of free help for each survey that is finished. These hours will be accessible whenever inside the initial 90 days of framework execution and can be for either remote help with an electronic stage or by means of telephone. Quantifiable Organizational Value We will likely execute another ERP framework that will consolidate the information obtained from every area in our facilitated condition and make open to every area. This will be done principally by utilizing Structured Query Language (SQL) and Microsoft based announcing administrations.

Professional Career Goals Essay

Professional Career Goals EssayEveryone who has ambitions to be a doctor or an engineer has been given a variety of career planning tips by the university counsellor. It is obvious that everyone is advised to aim for the higher positions so that they can earn more and get promoted faster. So, where do you find sample essays to write for medical and engineering career?It is a way of expressing one's values and interests in life style, community work, and career development. Most schools give their students practice writing for a medical career related essay. The teachers guide their students with all the aspects of good writing.These essays are also a way of helping students have their own lesson plans in life. They may use these as examples when they prepare to do their own projects. It is a good idea to have sample essays prepared, and then you will be able to determine what your skills are.Career oriented questions are very common in the job applications that are being sent out for applying for various positions. Medical school, or even the high school are bound to ask these type of questions. It will help them understand the type of person that they want on their institution and how they plan to motivate them towards their respective career.Other than these questions, career testing is another aspect of training and coaching. It tests the candidate's general knowledge in a field in order to measure their level of knowledge. This is a very good idea since most people will find themselves asking these type of questions at some point of time. A test like this should be free of charge, and there should be no problem in obtaining it if needed.Sample essays for career goal should be such that it can be easily used and should present the best ways of dealing with different issues. For example, there are various career assessment question types such as, 'What is your sense of humor?' and 'What is your greatest achievement?'The essays should also reflect your interes ts, values, personal values, and interests. It should also make it easy for you to convince others to be a part of your job. You should think of an answer that will make your essay stand out and help you catch the attention of potential employers.When preparing for your essay, think of something that you will never forget. For example, it would be a great idea to record a short film that would play during the interview session. There are lots of places that will give you samples for free; just do a Google search for sample essays and follow the links.

Should We Be Funding Domestic Violence Shelters Essay

Should we be funding Domestic Violence shelters? Domestic violence is a problem in our country with nearly 1 million women experiencing at least one incident of domestic abuse each year, (2009/10 British Crime Survey). Social-program funding is being scrutinized in the current economic climate with doubts as to whether American tax dollars should be used to help victims of domestic violence. Cutting funds for government programs that assist victims of domestic violence is not an option for many reasons. In this essay I will explore some of the many ways these programs help our fellow citizens in order to support the argument for continuing to fund said programs. 54% of women victims of serious sexual assault were assaulted by their†¦show more content†¦76% of all DVincidents are repeat, (Flatley, Kershaw, Smith, Chaplin and Moon 24). 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Should Marijuana Be Legalized - 1340 Words

The argument of legalizing medicinal marijuana and marijuana used for recreational purposes has been around for quite some time now. Recreational use is when one smokes cannabis just for fun and with the intention of altering the state of consciousness while medicinal marijuana is used for treating certain maladies and alleviating their symptoms. Though marijuana use is not as harmless as many people seem to believe. Like any other drugs, marijuana can affect the body and mind and may have a majority of side affects. It has an addictive nature and is also known as the gateway drug. It can even affect those around you in more ways than one. For instance if something were to happen to you or if for whatever reason you lash out at them. The†¦show more content†¦The problem has not only happened in Colorado but in other states were the use of cannabis is legal. For example, in the article, â€Å"Odd Byproduct of Legal Marijuana: Homes That Blow Up†, by Jack Healy, he says â€Å"Over the past year, a hash-oil explosion in a motel in Grand Junction sent two people to a hospital. In Colorado Springs, an explosion in a third-floor apartment shook the neighborhood and sprayed glass across a parking lot. And in an accident in Denver, neighbors reported a ball of fire that left three people hospitalized.† Innocent lives are getting hurt because now that recreational marijuana is legal in colorado people think that it is also legal to extract hash-oil from it and that they don t have to pay the crime if someone gets hurt. â€Å"I view this as an equivalent of frying turkey for Thanksgiving. Someone spills the oil, and theres an explosion. It’s unfortunate, but it’s not a felony crime.† (Healy) So then who pays for the crime of someone getting hurt? Simply because it is now legal does not mean that it is a get out of jail free card. That is only an excuse to get away with it because at the end of the day the explosion still occurr ed and people got hurt. More and more accidents like this will occur if other states legalize the use of Marijuana. As I have said, the use of marijuana also alters ones reasoning and

Environmental Economics Essay - 1937 Words

Introduction With the rampant deterioration of the environment taking place, panic striking and scandalizing environmental issues like global warming and greenhouse effect making banner headlines in our news papers and bulletins. Entire world is busy in devising energy reforms that can save the planet from plunging deep into the pit of destruction and catastrophe. In order to counter the looming energy crisis that is engulfing the world, research scientists all over the world are busy brainstorming their ageing heads in order to devise reliable energy systems, which can prove effective in resolving environmental disasters. (Costanza, 1991) In order to achieve this objective, substantial progress has been made in the form of†¦show more content†¦A question that can justly be asked here is why the exploration of renewable energy resources still in its embryonic stages? 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(LINES OF EXPLORATION) Nigeria faces vast inequality with a gini coefficient standing at 48. 8 (United Nations Development Programme, 2013). Lagos is home to the largest slum in the country, which is Ajungle. Nearly thirty kilometers away from the cities largest slum is a landfill where nearly 1000 people live and work

Examination In To The Impacts Of Changing Customer Needs - Sample

Question: Discuss about the Examination In To The Impacts Of Changing Customer Needs, Such As Increasing Or Decreasing Product Or Service Usage In The Global Business. Answer: Background research and academic context Customers are the main stakeholders in a business context as they act as the target market under which the business is formed. Products and services provision by the business owners to the customers depend on their needs and requirements resulting to specific levels of demand. A change in the needs and requirements of the product or service provided to the customer depends on change in customers preference that should always be respected by the business owners. This is an important aspect in global business market as product and service provision satisfaction enhances customers loyalty to the responsible business unit (Goetsch Davis, 2014). Academic context relating to the changing customers needs relates the aspect to various measures in which both the wholesalers and retailers can put in place to ensure they understand needs and requirements of their specific customers. This can be done by ensuring they keep a clear record to help understand the trends of their customers behavior in buying their products as well as services. This is important to ensure that the business owners can come up with strategies to help cope with the changing customers needs to provide according to their various preferences (Millum Sina, 2014). Research objectives Specific objective To examine the impacts of changing customers needs in the global business market General objectives To identify the various types of customers in the market, either direct or indirect from the chosen target market. To identify the various types of needs and requirements by the existing customers in the global market business. To identify the various reasons for the change of customers needs in the market. To identify how change of customers needs in their specific products and services impact on global business market. Research methods To ensure effective data collection in this research, both quantitative and qualitative methods of data collection will be enhanced. Quantitative method to be used in this case is use of questionnaires structured in a way that the customer can easily understand and answer regarding to preferences of a particular product or service in the market (Hair, 2015). Sampling technique is also a method of data collection that will be used to acquire related information from a sampled group of customers regarding to the preference of the product. Qualitative method to be used in this case is use of case studies, this involves a researcher to identify an efficient existing case relating to the research problem. The researcher identifies the existing case and studies it to identify relevant data relating to the study (Solomon, 2014). Research ethics Research ethics in this case refer to ethical principles of research that needs to be strictly followed during research and apply to both the researcher and the participants. They include: Follow the given consent rules, example in acquiring a case. Give honest and valid data. Ensure confidentiality and privacy of the participant. Be conscious of researcher various roles. Time scale and resources Time scale of the project depends on the various activities to be enhanced during the period of carrying out the various project research activities. The resources required to carry out research activities in completion of the project include adequate finance to buy various questionnaire materials, to compensate for various services like transport fee to meeting the customers among other costs. Timetable for project research Activities Month Research Activity December January February References Goetsch, D. L., Davis, S. B. (2014). Quality management for organizational excellence. Upper Saddle River, NJ: Pearson. Hair, J. F. (2015). Essentials of business research methods. ME Sharpe. Millum, J., Sina, B. (2014). Introduction: international research ethics education. Journal of Empirical Research on Human Research Ethics, 9(2), 1-2. Solomon, M. R. (2014). Consumer behavior: Buying, having, and being (Vol. 10). Upper Saddle River, NJ: Prentice Hall.

How Does Crime Affect Society free essay sample

To bring up children Bringing up children Q: There has not yet been any decision made _______ will represent the country at the Olympics. concerned athletes chosen as to which athletes those athletes Q: ______, Shakespeare was also a prolific writer of sonnets. Noting for his plays Famous plays Noted for his plays Q: The Concord, which was ______________ jet, could reach New York from London is approximately 2 and 1/2 hours. fastest in the world the fastest of the world the worlds fastest Q: Scientists _____________ nano-technology capable of computation at the atomic level. newly have developed have recently developed ave still developed Q: ________ is portrayed in Hermann Hesses Steppenwolf. Man searching his soul A man searched his soul A man in search of his soul Q: Despite ____________, Jack continued to lose weight. he increased his food intake increasing food intake increased food intake Q: Singer and entertainer, ____________ for his beautiful and expressive voice. We will write a custom essay sample on How Does Crime Affect Society or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page was Frank Sinatra famous famous was Frank Sinatra Frank Sinatra was famous Q: It is not only important to be on time, __________ courteous when replying to colleagues. but also is it important being but is it also important to be but it is also important to be Q: ______ was this check written? To who Whom To whom Q: Children attending private schools ____________ being slightly spoiled. are often accused of often accused are often accused from Q: Diets based on only one basic food element ____________ no diet at all. can be as ineffective than can be as ineffective as can be so ineffective than Q: _________ that James Franklin made his stunning debut. It was Lions It was in Lions Lions it was Q: Considering human history, it ______________ using mass communications. has recently been that man is only recently that man has begun only recently is that man has begun Q: That test was _________________ . such difficult that I almost failed as difficult that I almost failed so difficult that I almost failed : Within Tuscany ___________ Matthew Spender. is written from was written from was written by Man| My car is broken down. | Woman| Ill pick you up. | Narrator| What does the woman imply? | | | | Shell give the man a ride. | | Shell take the car to a gas station. | | Shell look for a new car. | | Shell ask for help. | Woman| Looks like its going to be a nice day. | Man| Yes, its about time. Spring is just around the corner. | Narrator| What does the man imply? | | | | | Spring will come soon. | | He likes nice days. | | He cant wait until spring is here. | | Its about time for the weather to change. | Man| Can you believe the science project is due in two days? | Woman| That cant be so. | Narrator| What does the woman mean? | | | | | | She cares for the science project. | | She doesnt know how to complete the project. | | She cant believe the wor k is due so soon. | | She doesnt like kidding. | Man| Todd got the highest grade point average in the biology class. | Woman| No wonder! Hes at the library everyday. | Narrator| What does the woman suggest about Todd? | | | | | He doesnt come to biology class. | | He is studying all the time. | | He loves doing research at the library. | | He doesnt care about his grade point average. | Man| You like tennis so much why not take some lessons? Hmm they start next week. | Woman| How am I going to fit that into such a tight schedule? | Narrator| What does the woman mean? | | | | | | She doesnt think hes a good tennis player. | | She knows tennis will make her fit. | | She has no time to play. | | She wont start taking lessons next week| Woman| Would you mind going grocery shopping with me? Were out of everything. | Man| Id rather not. Cant you go yourself? | Narrator| What does the man mean? | | | | | | He doesnt need food. | | He prefers eating out to grocery shopping. | | He doesnt mind going with her later. | | He wants her to go alone| Man| It looks like theyre getting ready to start the highway project again. | Woman| Im not surprised. | Narrator| What does the woman imply about the project? | | | | | | The projects been going on for some time. | | She seems to need more time to get ready. | | The highway project started not too long ago. | | She wouldnt like to be surprised| Woman| Hes crazy about the comics in the Sunday newspaper.

Repercussion of the Reformatio essays

Repercussion of the Reformatio essays The Reformation first spread to the Netherlands and Scotland, where it was used as a vehicle for self-determination. The Reformation spread to France, and a Protestant religion was formed, the followers were called Huguenots. Calvinism became dominant in Scotland. In England, Henry VIII wished to divorce his wife, Catherine of Aragon. When the Pope refused to annul the marriage, Henry divorced her and Henry VIII was excommunicated from the Church. Henry created a Protestant religion, which was run by the Anglican Church. Healso urged Parliament to pass the Act of Supremacy, making the Monarch head of the Anglican Church; The Act of Supremacy was passed. Thus, one of the greatest revolutions of all time was the Reformation: a conflict sundering Catholics and Protestants during the 16th and 17th century; in consort, new beliefs and faiths emerged from reformers (Martin Luther) along with the Counter-Reformation, impacting the people. Although most people during the Renaissance disagreed with medieval ways, the rich Catholic Church still preserved many medieval ways. People began to disagree with Church customs. In the late 1300's, an English priest and teacher at Oxford University, named John Wycliffe declared that people should be able to read the Bible for themselves. Although the Church protested, Wycliffe's followers translated the Bible into English and handed copies out all over the English countryside. His ideas soon spread into Bohemia, where a preacher named Jan Hus spread the ideas even more. The ideas of Wycliffe and Hus influenced the most important reformer, a monk named Martin Luther. Luther had protested for years that many clergy were selling indulgences: pardons for sins without making it clear that people must sincerely repent their sins. He attacked the monk Johann Tetzel for deceiving the people. Eventually, he became angry enough, nailing a complaint, called The Ninety-Five Theses, to a Church door. The Nin...

The Reproductive Health Bill Essay Example | Topics and Well Written Essays - 750 words

The Reproductive Health Bill - Essay Example The bill has been unanimously approved by the House Committee on Population and Family Relations last January 31, 2011. It is now awaiting approval on third reading in Congress after which it will be submitted to the Senate for approval and eventually submitted to the Office of the President for signature (Montenegro, par.2). This process however is not an easy route. Various contending factions have their own vocal supporters from prominent groups and personalities in the fields of the academe, government, civil society and the religious. It is worth noting that the powerful Catholic Church, representing Catholics who comprise around 80 percent of the Philippine population (Santos, par. 4), is in the forefront of the campaign against the bill. The RH Bill seeks to guarantee universal access to family planning methods. The bill also aims to provide universal access to information on contraception and maternal care, and promote age-appropriate sexual education to youths in elementary and high schools (Palmer, par. 5). The bill seeks to protect the health and lives of mothers who die from unnecessary causes in childbirth, prevent unintentional pregnancies and thereby prevent abortions. For the bill’s proponents, one of the primary reasons why they wrote the bill is the interconnection between rapid population growth and poverty, with much of the growth in population occurring among the poor. In a 2004 study, the Asian Development Bank cited the country’s large population as one of the core drivers of the country’s poverty (Palmer, par. 2). Ernesto Pernia, an economics professor points out that with fewer children and wider birth intervals the poor will be able to devote more of their very limited resources to each child’s education and health which in turn will increase their chances of climbing out of poverty (Palmer, par. 7). It is worth mentioning that not all religious groups are against the RH Bill. The Philippine Council of Evang elical Churches supports the RH Bill because it is pro-life, pro-development and pro-poor. Addressing the concerns of the Catholic Church that the bill promotes a â€Å"culture of death† by allowing artificial contraceptive methods, its leader Bishop Efraim Tendero had this to say: "Life begins at fertilization. Therefore if there is no fertilization, there is no life yet. The use of artificial contraception is not taking away life because life has not yet started." (Santos, par.5 & 7). Another influential religious group, the Iglesia ni Cristo (Church of Christ), believes that the RH bill will help decrease many of society’s worsening ills which could be attributed to the increase in population. The group’s stand is with the RH bill, married couples can avoid unwanted pregnancies (Santos, par. 7-8). Another group, the Interfaith Partnership for the Promotion of Responsible Parenthood considers the RH bill as necessary to prevent the deaths of mothers and babies (Santos, par. 11). Leading the groups against the RH Bill is the Catholic Church. The Church supports Natural Family Planning, which includes abstinence and fertility beads among women. But it strongly prohibits the use of artificial means, such as birth control pills and condoms because it prevents human life (Palmer, par. 11-12). The Church argues that by making contraceptives universally accessible and promoting sex education in schools, it will promote promiscuity (Palmer, par. 13). But proponents argue that that is exactly why the proposed sex education of the youth includes values formation. The Church believes there is no relation between population size and poverty. They argue that instead of spending P6 billion in implementing the bill, it should instead be used

AN INTERVIEW WITH A LAW ENFORCEMENT OFFICER Essay

AN INTERVIEW WITH A LAW ENFORCEMENT OFFICER - Essay Example The main reason why I loved the idea of having this interview with Officer McGinnis while at work was because this was a rare opportunity for me to get a first hand information and experience how it feels to be a Police Officer on patrol. It was also pretty much to have a feel of being above the law without worrying that I might get pulled over for speeding since I was with an officer. One thing that came to my attention during that ride was that other drivers, especially on I-435W, drove more courteously. Nobody seemed to have over sped since they all drove within the speed limit and behind McGinnis’ cruiser. Inside the car I also noticed a lot of equipment which were used in police work and this really surprised me. Back home policemen had only a radio to communicate and a gun to protect them. Officer McGinnis explained to me that different police departments had their own jurisdictions, capabilities and respective responsibilities to maintain law and order that require state-of the-arts technology. One question I raised during the interview was on what different kinds of challenges did he experience while on- and off- duty. According to Officer McGinnis, one of his greatest challenges he faces as a police officer starts daily with the half hour briefings on legal issues which he is expected to know. Other challenges he faced include the continuous rapid change in technology (hi-tech gadgets) which he has to grasp and learn fast. They are constantly trained and retrained to update them on everything including new weapons used by criminals. They have been equipped with new laptops in the squad cars that were developed by the military, computer aided dispatch and laser pads for fingerprinting which they must learn how to use. He also explained that they have to be informed or updated all the time to prepare them for any crucial situation they might encounter while on duty. He was careful to point out that police work was not all car chases, lights and

What are The Benefits of Process Writing

What are The Benefits of Process Writing The writing process is an amazingly productive, constructive, and effective method of writing. This method is undeniably the best method in order to help a writer reach their full potential. The writing process is undeniable because anybody who has used this process has realized the benefits. The process is simple and only requires patience, revision, and the willingness to better ones work. It involves prewriting, revising and rewriting your work if necessary in order to ultimately achieve the best writing you are capable of. We almost never write to the absolute best of our ability on the first draft; which is why the writing process proves to be so successful. Process writing utilizes careful revision and rewriting techniques to effectively help writers compose their ideas into clear, concise, and well thought out statements that represent their style and passion for the subject. Any modern day writer should be familiar with this process because it is necessary to achieve quality writing. Many theorists and writers have written books on writing as a process and almost anyone who has tried the process would agree that it does in fact work. Initially, the first thing a writer should do to completely prepare themselves for the task at hand is organize their ideas. They should take the time to formulate a main theme or point which they are trying to convey as well as possibly do some prewriting activities such as brainstorming, drafting an outline, or free writing. This step is referred to as prewriting in the writing process and can be extremely useful to a writer that is trying to figure out their main idea or focus of the paper. Prewriting can be as simple as just writing your ideas out onto paper; it is important to remember to just keep writing and not to over analyze anything at this step in the process. The idea is just to get all your thoughts out onto paper so the best possible ideas can be formulated into a well written cohesive document. After prewriting has been completed the writer can now comprise a first draft. This draft can then be revised and possibly critiqued by other people as well as yourself. Revisi on is an essential part of the writing process because it gives the writer the chance view their paper threw someone elses eyes. It allows for criticism and discussion which eventually make the writing more powerful and meaningful. Since the writing process allows for revision over time the writers work transforms into something that is very well thought out and written much better than their first draft. After revision, comes probably one of the most challenging steps in the writing process which is known as rewriting (Flower). Donald Murray once said writing is rewriting (Murray). This short statement is as true today as it ever was. In order to create something that is well written you must write and then re write your thoughts which ultimately makes them well thought out and meaningful. Rewriting is such an imperative part of the writing process which is why Murray feels rewriting is just as important as writing the initial draft (Murray). The rewriting step in the process helps the writer narrow down their initial statements into what they truly want to say. Good writing or good English as described by William Zinsser is often the outcome of this step in the writing process. Writers often further relate to the audience as a result of this step by fabricating their ideas into something that most people can relate to and understand. Using common words that everybody can relate to can really help your reader feel connected or associated with the content they are reading. Ordinary everyday sentences are oft en clear, concise, and brief. These ordinary sentences push the writing forward by making the reader ask more questions about what is going to happen next. In order to write good English a writer must cease the use of unnecessary language and keep their sentences short, simple, and to the point so the reader can truly understand and relate to the content (Zinsser). Even though this may seem like the end of the process you should really repeat the revision and rewriting steps a few times in order to achieve the best possible results. Many writers including myself have seen the writing process work over and over again. I have seen the benefits of the writing process in my own writings many times. Every time I write something and just hand it in without any type of revision I always notice I could have written it much better if I had simply read through it and revised it. Also, whenever I do have the chance to get a peer revision on my writing I always notice that the final product is undoubtedly much better than the first draft. Sometimes I only want to write a single draft because I procrastinate until the last minute and dont have time for the writing process. If this is the case my final draft usually suffers in quality. Often times my lack of revision isnt hard to miss because the final draft usually ends up littered with typos or incoherent run on statements. If I had simply revised my work once the quality would have greatly increased. The writing process is also very important for students learning to write because it gives them the chance to critique and discuss their own writings as well a s other students writings in the class. Ultimately, one of the real reasons most people write is because they can not only speak out and express themselves to the world but they may also influence others with their ideas. There are so many great things a person can do with the power of word. Whether it is to persuade, inform, narrate, or inspire, good writing is something that can be appreciated by all and is a very powerful tool. If you aspire to write well then using the writing process correctly is something that must be on your top priority. After all, a well thought out meaningful sentence is a weapon of great power in our literary world.

The Old Man and the Sea :: Essays Papers

The Old Man and the Sea The Old Man and the Sea Hemmingway, Earnest FVL Library 138 pp. The main theme of Hemmingway's The Old Man and the Sea, is not an easy one to pick out. At first glance the book seems to simply be a story about a guy who goes out and battles with a fish. However, there has to be some underling theme. It could be the relationship between a boy and a man, and how both are treated by nature. This is illustrated by the boy's parents not allowing him to continue with the unlucky old man. It is also shown by the success the boy had and the failure the old man experienced after their parting. Still through all of this the boy remembers how well the old man treated him and does everything he can for the old man. On the whole, I liked this book. It was written in relatively easy to follow language, yet Hemmingway was still able to convey unbelievable images of picturesque settings in the reader's mind. There is also an interesting use of dialog, not only between the boy and the old man, but es pecially with the old man talking to himself. This is something I really haven't seen used that extensively. I think Hemmingway used this to fill in the parts of the story where the old man is simply at a stalemate with the fish, when he is just sitting there being pulled around the ocean. The one thing I didn't understand about this one sided conversation was the constant reference to Joe DiMaggio. I don't know if this was simply a tribute to a great ball player, or some kind of historical reference that I just didn't get. The pace and general flow of the story was good. There were a few times during the struggle where the action all but disappeared, but on the whole there was almost always something happening. The plot was also pretty simple and easy to follow. Another quality of this book which I have seen in others I have previously read was the complete lack of a male-female love subplot. As I have said before, this often times just messes things up. In this case the only love affair was between the old man and fishing. However I would not say there was love between the old man and the fish.

Life is what you make it Essay

A little boy called Andy was asked to audition with his classmates for a part in the school play. His mother knew that he had his heart set on being in the play and she was worried about how he would react if he wasn’t chosen. On the day that the parts were given out, Andy’s mother went to the school to collect him feeling anxious about the outcome. Seeing his mother Andy rushed up to her, his eyes were shining with pride and excitement. â€Å"Guess what Mum,† he shouted, and then said the words that can provide a lesson to us all, â€Å"I’ve been chosen to clap and cheer.† Understanding and knowing that you are so much more in control of your lives than you sometimes believe is not only reassuring, it is empowering. The way that you think determines the way that you feel and is the control pad for the volume of happiness that you can experience. The quality of your thinking essentially determines the quality of your life. Think about this †¦. Did you know that you have 60 – 80,000 thoughts a day ? Yesterday I had a thought. That thought became an emotion That emotion turned into words, the words fuelled action, The actions became a habit. My habits are my Character, My Character defines my destiny. Today, therefore, I’ll think about my thoughts a little more. The power of positive thinking Thinking positively is not about putting your head in the sand, nor is it  about being unrealistic. By developing a positive attitude you still recognise the negative aspects of a situation, however you choose to focus on the hope and opportunity that is available. This approach helps you to avoid getting locked into a paralysing loop of bad feeling and allows you to move on quickly and take action to solve problems and embrace life’s challenges of which we inevitably experience. This quote says it all! â€Å"Whether you are an optimist or a pessimist might not affect the outcome, it’s just that the optimist has a better time in life!† James Borg – Mindpower The term â€Å"PMA† is all about having a positive mental attitude. Many books about personal success or self-improvement start with a sharp focus on cultivating energy, enthusiasm and optimism in all areas of your life.. Developing a positive attitude is the key to health and happiness. Sustaining a positive attitude Creating and maintaining a positive attitude is the most efficient and low-cost investment you can make in order to improve your life. A positive way of thinking is a habit and needs to be learned through repetition and conscious effort on your part. Positive affirmations to condition your mind can be very useful. Saying things to yourself like: I am an optimistic, hopeful, positive thinking person. Yes I accept that bad things can happen in my life, however I choose to look for positive opportunities and outcomes in every situation. A positive attitude is not dependent upon your genetic composition even if you are pre-disposed to negative thinking you can learn to move your thinking to the positive side. This depends entirely upon you and how you choose to think. How to be more positive about your life Avoid negative attitude germs Let me ask you a question. If you had a really bad cold or flu would you walk over to someone and sneeze in their face? Hopefully not!  So let me ask you another question. Have you ever had a bad day when someone or something has annoyed or upset you and you have felt the need to get it off your chest and have a good old moan to someone about it? I am sure that we have all been guilty of that from time to time. You are, in effect, spreading your NAGs – Negative Attitude Germs. You may have noticed that when you are with someone who is suffering from a physical or emotional problem, you feel bad too. It’s often described as catching their emotion. Researchers have observed this actually happening in real time in the brain, using an advanced MRI (Magnetic Resonance Imaging) machine. It shows the brain of Person A reflects activity in the same area as Person B when they are in close proximity. The scientific term for this is neural mirroring. This does, therefore, point out the danger of hanging around negative, pessimistic people if you prefer to be positive and optimistic. Choose to be a radiator Some people you meet are like drains: negative, listless doom goblins and when we come into contact with them they drain us of energy. They like to tell you about all their negative news and prefer to play the victim, wallowing in the â€Å"poor me† mentality. These are the people who when you ask them how they are they will respond with their shoulders slumped, eyelids drooped â€Å"Well you know †¦ I feel really †¦ bad!† and then they will give you a graphic blow by blow account of all their woes and feelings of impending  doom! You may well know people like this. Perhaps it is a behaviour you indulge in? Perhaps we all do from time to time however does it really do us any favours? Other people, however, are like radiators – full of warmth and vitality. We feel positively energised by them. They appear bright and radiant, look you in the eye and when you ask them how they are, they smile and tell you something positive. It is amazing how some people are so intent on being negative. I wonder whether they get up some days and plan to go into work to â€Å"drain the radiators†! You may well know people like this. It might even be a behaviour that you indulge in yourself. If so, next time you find yourself doing this ask yourself how you will positively benefit from actively choosing this mind set. Take personal responsibility The antidote for negativity is that you learn to accept responsibility for your situation. The very act of taking responsibility cancels out any negative emotion that you may trigger. By embracing responsibility you will reap many rewards. The successes brought by this attitude acts as a foundation for selfrespect, pride and confidence. Responsibility breeds competence and personal power. By living up to your promises and obligations, you will win the trust of others. Once you are seen as trustworthy, people will willingly work with you and want to be with you. Making excuses can put the brakes on our progress, while accepting responsibility can lead us more towards succeed. It can be easy to blame others or circumstances for everything in our lives – past, present or future. It lets us off the hook to some degree. However, ultimately it doesn’t help us because we become a prisoner of circumstance and allow everything and everyone around us to dictate our world. Positively learn from mistakes Making mistakes is human and we can’t get everything right all the time. To increase your rate of success you will have to be willing to accept that you will make mistakes along the way, the skill is that you positively learn from them. Certainly some of the best learning and character building experiences I have been through are on the back of mistakes. Mistakes are the portals of discovery James Joyce Putting your hand in the air and saying â€Å"yes I recognise I made a mistake or I am responsible for that and this is what I am going to do to improve the situation† is actually quite liberating.  For example admitting when we get something wrong and saying I’m sorry can relieve a great deal of tension in any relationship. Humble pie can actually taste quite nice! It isn’t poisonous. It is a real skill to be brave enough to admit when you don’t get something right and have the humility to accept it, admit and then positively move on. Just because you mistakes it doesn’t make you a lesser person or inferior to others. Also if you never make mistakes, how do you learn? No-one can make you feel inferior without your consent Life can be an interesting and challenging journey and granted you may well get a little travel sick along the way and you may even hit a few pot holes. However, by developing a positive attitude you will be much better equipped to be able to deal with everything so much better. It takes practise and  certainly there will be days when you really struggle to see the sun for the clouds. You may even decide you want to wallow a little and that is ok. The question though, is for how long? Life is what you make it and what makes your life worth living is your own personal voyage of discovery. We are all people in progress with so much undiscovered potential. How exciting and wonderful is that? Life is what you make it – Top Tips The first step to happiness is to make a conscious decision to be happy Choose to be an optimist not a pessimist Actively seek out opportunities instead of problems Think more consciously about what you think about Address any negative attitude germs that you may be spreading Choose to be a radiator not a drain Avoid blaming other people Learn from your mistakes and positively move on Take personal responsibility for all your actions Remember this is your life and your life is what you make it About the author Liggy Webb is widely respected as a leading expert in the field of Modern Life Skills. As a presenter, consultant and author she is passionate about her work and helping to improve the quality of people’s lives. Her new book How to be Happy (Published by Capstone) is due out in August 2012. It will be available on Amazon and in all book stores. Email info@liggywebb.com to order a first edition signed copy. This makes an ideal gift and can be gift wrapped if requested at no extra charge. Liggy Webb explains how we can achieve a happier and more positive life and  backs up her theory with some great evidence and advice. Paul O’Neill, Vice President, Guinness World Records Commercial This is a life enhancing book that will undoubtedly bring greater and longer lasting happiness to every reader’ Richard Denny, International Business Growth Specialist, Speaker and Author

The Holocaust Survivor - Free Essay Example

Sample details Pages: 6 Words: 1794 Downloads: 5 Date added: 2019/04/26 Category History Essay Level High school Tags: Holocaust Essay Did you like this example? Even in his old age, Vladek still does his best to take care of himself as he pedals on his bike. This tendency was hard-wired into him during his time in the concentration camps: only the fit and the strong survived as they were valued over those who were weak and sick. Artie has clearly talked about chronicling Vladeks life during the war before, and Vladek suggests he sticks to what he is good at instead, apparently reluctant to reopen old wounds. Don’t waste time! Our writers will create an original "The Holocaust Survivor" essay for you Create order In the fifth panel of the page, Vladeks prisoner number can be seen: one of the few remaining tangible reminders of the horrors he endured in the camps. It also hammers in the fact that Vladek is a survivor and that the Holocaust as it is for all survivors will always be a part of him. Artie is Jewish; however, he is not a Holocaust survivor like his father. Vladek may be in denial or does not realize it, but Artie knows that Vladeks experience as a survivor is a tremendous responsibility. Artie knows he is not fit to tell Vladeks story, he has never met any of the people in Vladeks life and does not have all of the information necessary to authentically depict the scenes Vladek describes. However, that does not change the fact that Arties family was almost wiped off the face of the planet during the Holocaust and he feels an obligation to preserve Vladeks memories out of respect for the suffering he endured and ensure the atrocities of the Holocaust are never forgotten. However, it is also worth noting that Arties first question about his fathers past shows how little he truly knows about him and how fragmented their relationship is. He does not even know how his own parents met. This foreshadows more unrest to come in later chapters. It is also a stark contrast f rom Vladeks life where familial bonds were an integral part of human life, even going so far as to sustain them and kept them alive. Artie is clearly distant from his family and very independent of them. Vladek and Mala are not happy together, but her and Artie seem to get along reasonably well. Artie treats her with respect and ignores Vladek when he tries to speak poorly of her, suggesting that perhaps Mala is not as bad as Vladek says she is. Arties stories about food and the dinner table hint at deep tension and brokenness and unhappiness in his family that everyone present at the table wishes not to address. Both Artie and Vladeks relationships have been fractured by the ruin of the Holocaust and the trauma brought by Anjas suicide. However, they are both selfish and neurotic, and both are too proud to address their shortcomings. The Holocausts effects on Vladek are also present in almost every aspect of his life, especially in his interactions with Artie. It is apparent that even from the beginning of the first novel where Vladek asks Artie to test the sincerity of his friends by locking them together in a room with no food for a week, that the Holocaust has shaped Arties entire life. He finds himself unable to relate to many of his fathers seemingly strange habits and mannerisms. Artie even tells his wife Francoise that he sometimes he could have been in Auschwitz with his family so he could better know what they went through and how it impacted them. Vladek is shown to be controlling and presumptuous by pitching Arties coat. He believes he knows better than Artie and Artie like a young child cannot make his own decisions. Vladek still thinks of Artie as a child despite the fact he is very much grown up. Artie tries to prove himself a man by berating Vladek but he is still forced to accept the hand me down, and like a child, he still has to what Vladek wants, even though it aggravates and that he is an adult. Artie strives to be as honest and upfront about Vladeks shortcomings as he can. He knows that despite all of the admirable qualities Vladek displayed, Vladek is not an uncomplicated, flawless hero and it would do Vladek a disservice to depict him as such. However, an unambiguously positive portrait would serve also allow Artie to vent his frustrations towards Vladek, which often seems to be the case. Artie is also distant from the love and compassion of his Jewish roots that his family displayed during the war even when they had little reason to live or persist living. This disconnect does not enable Artie to relate to what Vladek does or even see the good intent behind his actions although presumptuous. 4.) Vladek grows sick of hiding and wishes to be treated like a human once more. His frustration is justified, but regardless, he displays remarkable recklessness and stubbornness in asserting his decisions. He does not make an effort to understand Anjas anxieties nor does he exhibit any sympathy towards her. In such times of persecution, familial connections and friends were a crucial aspect to Vladek and Anjas survival. Parents, siblings, cousins, and friends all helped one another in any way they could even if they were not close before the war. While he is insensitive and reckless in this particular panel, Vladek still cares deeply for Anja, and Anja even states in a letter in Auschwitz that the fact he is alive is the only thing keeping her from throwing herself into the electric fence. All they had was each other, and Jewishness as Artie knew it became synonymous with survival under these circumstances. Artie is sharing his childhood insecurities with Francoise and how uncertain he was about his relationship with his parents. It also reveals the livings tendency to glorify or valorize the dead. Richieu did indeed die a tragic death, but he was still an ordinary person like Artie. Vladek and Anjas laud of Richieu was indeed a coping mechanism but revering his memory created tension among the living that was almost never resolved. Despite how hard Vladek has supposedly tried to forget about the Holocaust, he can recount the events in extraordinary detail and often cannot help becoming emotional as he relives his memories. He weeps when he remembers four of his friends hung in Sosnowiec and displays profound, parental grief when speaking of Richieu. Vladek displayed love and compassion constantly towards those around him, and that is what makes his memories so painful. Love like it did for so many Jews during the Holocaust, gave their lives meaning when the tyranny of the Nazi regime had taken all other reasons. Because Vladek and Anja loved so profoundly, they consequently hurt and mourn deeply as well. Nevertheless, comparing Artie to the memory of Richieu was unhealthy and contributed to Arties inferiority complex and widened the gap between him and Vladek. This panel portrays a number of different reactions to Vladeks life which perhaps represents how contemporary generations view the Holocaust. Artie remains firm in compartmentalizing his life and Vladeks, keeping them distant from one another. Francoise is sympathetic and tries to be very kind to Vladek in light of what he had to endure. The grocery store manager likely wished to end the conversation early and give Vladek what he wanted and instead of hearing the tales of cruelty and tragedy that Vladek had to endure. Both Artie and Vladek have a duty to share their experiences with the world. Both the survivors and those whose lives were touched by the tragedy have an obligation to share. By sharing, they contribute to the larger narrative of the Holocaust and help generations to come to make sense of the tragedy. Artie wrestles with whether or not it is right for him to share these experiences at all as he was not present and feels it is often not is place. The stories of the living, stories of triumph and overcoming impossible odds are often told, but in doing so, the perspectives of the dead are often forgotten. Artie is afraid he will misinterpret what Vladek tells him and in doing so dishonor the living and the dead. Nevertheless, while he cannot relate to the Holocaust the way that Vladek can, he has been molded by the tragedy, and the legacy of the event transcends generations. The Jewish people as a whole share it. While he is apparently willing to use his past to his advantage, Vladek st ill feels compelled to help Artie create an account worthy of the truth and gives those who cannot speak for themselves a voice. The mask that Artie wears is symbolic of his feeling of falsehood. He does not feel like he is worthy of his identity as a Jew and feels as though the story is not his to tell that he is profiting off the dead. He is unable to disconnect himself from his book, and his book persona has become intertwined with his real self. The dates he names show the passage of time as well as touching upon the thought of life and death and how they are interlocked in regards to the Holocaust. Artie is overwhelmed by the demands of success and his fear of doing the survivors and those who have perished a disservice. His ears and hair are visible from behind the mask he wears. The head of the mouse connects Jews over all nations and generations which suggests Artie feels as though he is a fraud and is hiding his true self. He feels as though he is unlike his parents and other Jews. This shows his anxiety about profiting off of a story that he feels he has no right to tell. The tombstone shows that Vladek and Anja are reunited in death. There is undoubtedly pain and complication that will persist after Vladeks death, but the peaceful grave quells these concerns. This is clearly a tribute to Arties love and forgiveness towards his parents. Artie knows that death does not resolve the relationship between him and his parents, but it is still a sign that Artie has moved forward and that love persists despite the conflict they endured in life. Artie has relinquished his anger and respects their memory peacefully. His story does not have an easy or pleasant ending, but Artie acknowledges the fact that he needs to let go. Arties peaceful release does not placate his wounds and suffering nor does it mend what his parents endured. The significance and depravity of a story such as theirs perhaps has no redemption. The last page shows that Artie must settle for some semblance of a resolution and learn to live with pain and anguish when he is unable to vanquish it himself.